Opposition to the War of 1812 was widespread in the United States, especially in New England. Many New Englanders opposed the conflict on political, economic, and religious grounds. When the Embargo Act of 1807 failed to remedy the situation with the United Kingdom, with Britain refusing to rescind the Orders in Council (1807) and the French continuing their decrees, certain Democratic-Republicans known as war hawks felt compelled to persuade the United States government to declare war on the British. A number of contemporaries called it, "The second war for independence." Henry Clay and John Calhoun pushed a declaration of war through Congress, stressing the need to uphold American honor and independence. Speaking of the impact of the depressed cotton trade upon his fellow Southerners, Calhoun told Congress that:

They see, in the low price of their produce, the hand of foreign injustice; they know well without the market to the continent, the deep and steady current of supply will glut that of Great Britain; they are not prepared for the colonial state to which again that Power [Great Britain] is endeavoring to reduce us. The manly spirit of that section of our country will not submit to be regulated by any foreign Power.

Vehement protests against "Mr. Madison's War" erupted in those parts of the country where the opposition party, the Federalists, held sway, especially in Connecticut and Massachusetts. The governors of these two states, along with Rhode Island, refused to place their state militias under federal control for duty outside the territory of their respective states. In the ensuing 1812 and 1813 United States House of Representatives elections, some members of Congress who voted for the war paid the price. Eight sitting New England congressmen were rejected by the voters, and several others saw the writing on the wall and declined to seek re-election. There was a complete turnover of the New Hampshire delegation.